Vatican/ˈvætɪkən/ Definition 1 of 3Pro Tip 1/3Geographic Specificity Vatican refers to a specific, independent city-state distinct from other Italian cities. The Vatican is governed by the Pope himself. Pro Tip 2/3Cultural Significance Vatican has cultural importance, being the location of significant art and architecture. Many tourists visit the Vatican to see the Sistine Chapel. Pro Tip 3/3Not Just a City While Vatican is a city, it's often used to symbolize the power of the Catholic Church. The Vatican influences Catholics worldwide.