Wakeful/ˈweɪkfl/ Definition 1 of 1Pro Tip 1/3Difficulty Sleeping Indicates someone can't sleep even when they're very tired. After the stressful meeting, she lay wakeful in bed. Pro Tip 2/3Mental Alertness Suggests being very aware and unable to relax the mind. The guard remained wakeful throughout his night shift. Pro Tip 3/3Anxious Watchfulness Used to show someone is worried and constantly attentive to their concerns. His wakeful gaze suggested he was waiting for news.