Ache/eɪk/ Definition 1 of 4Pro Tip 1/3Body Part Specific Ache often refers to pain in a specific part of the body rather than general pain. She had an intense headache. Pro Tip 2/3Persistent Pain 'Ache' implies a lasting pain, less severe than sharp or sudden pain. His toothache wouldn't go away. Pro Tip 3/3Less Intense Ache is less intense than agony or torment but can be constant. The dull ache in her shoulder persisted.