Affliction/əˈflɪkʃn/ Definition 1 of 4Pro Tip 1/3Emotional Weight Used to describe situations with serious emotional impact, often associated with pity or sadness. His mother's passing was an immense affliction. Pro Tip 2/3Not Always Physical Can refer to emotional pain, not just physical suffering or diseases. Rejection was an affliction she carried silently. Pro Tip 3/3Long-lasting Effect Implies a condition that persists over time, rather than a brief episode. The affliction of loneliness plagued him for years.