Affliction

usgb/əˈflɪkʃn/Volume
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Emotional WeightPlay
Used to describe situations with serious emotional impact, often associated with pity or sadness. SlideHis mother's passing was an immense affliction.
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Not Always PhysicalPlay
Can refer to emotional pain, not just physical suffering or diseases. SlideRejection was an affliction she carried silently.
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Long-lasting EffectPlay
Implies a condition that persists over time, rather than a brief episode. SlideThe affliction of loneliness plagued him for years.