Buddy/ˈbʌdi/ Definition 1 of 5Pro Tip 1/3Close Friendship Use when referring to a very close friend, often one you spend a lot of time with. I'm grabbing lunch with my buddy after class. Pro Tip 2/3Emotional Bond Suggests a bond beyond casual friendship, with mutual trust and support. My buddy was there for me during tough times. Pro Tip 3/3Gender Neutral Although commonly used for men, 'buddy' can be gender-neutral. Jess is my best buddy at work.