Depart/dɪˈpɑːrt/ Definition 1 of 4Pro Tip 1/3Physical Movement Use 'depart' when someone moves from one specific place to another. She will depart from Chicago at dawn. Pro Tip 2/3Planned Time 'Depart at' usually indicates a scheduled time for leaving, often in transport. The flight is scheduled to depart at 6 PM. Pro Tip 3/3Preposition Choice After 'depart', use 'from' for starting points and 'for' for destinations. The bus will depart from Leeds for Manchester.