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Emotional WeightPlay
Despise conveys a strong negative emotion, stronger than just disliking someone or something. SlideShe despised the bullying, feeling a deep sense of injustice.
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Intensity MattersPlay
Use despise to express a powerful aversion; it's much more than just not enjoying something. SlideHe despised having to work late on weekends.
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Personal RejectionPlay
Despise often implies a personal element of contempt or disdain, especially in betrayals or moral clashes. SlideEveryone despised the traitor for his selfish actions.