Despite/dɪˈspaɪt/ Definition 1 of 1Pro Tip 1/3Context Clarity Use 'despite' to highlight a surprising contrast or unexpected situation. Despite the bad weather, the event was well-attended. Pro Tip 2/3Positive Emphasis 'Despite' often precedes a positive turn of events or quality, especially after something negative. He smiled despite the pain. Pro Tip 3/3Emotional Nuance 'Despite' can convey a sense of perseverance or determination against challenges. Despite many setbacks, she completed her novel.