Homeboy/ˈhəʊmbɔɪ/ Definition 1 of 2Pro Tip 1/3Familiar Tone Used among friends to express trust and close relationship, not in formal situations. When I got the news, I called my homeboy to talk. Pro Tip 2/3Endearment Shows affection when referring to a friend, similar to 'brother' or 'buddy'. My homeboy always has my back. Pro Tip 3/3Non-Gendered Typically refers to males, but can be used for close friends of any gender. She's like a homeboy to me, always joining our basketball games.