Homie/ˈhəʊmi/ Definition 1 of 2Pro Tip 1/3Informal Usage Use 'homie' in casual settings, never in formal or professional situations. Can't wait to catch up with you, homie. Pro Tip 2/3Positive Bond 'Homie' implies a positive friendship and trust, not just any acquaintance. You're my homie, I've got your back. Pro Tip 3/3Gender Neutral The term 'homie' can be used for any gender; it's not gender-specific. She's been my homie since kindergarten.