Injection/ɪnˈdʒekʃn/ Definition 1 of 5Pro Tip 1/3Medical Procedure Refers to a procedure where medicine is administered through the skin using a needle. He receives an insulin injection daily. Pro Tip 2/3Healthcare Settings Commonly used in hospitals, clinics, and by healthcare professionals. The doctor ordered intramuscular injections of antibiotics. Pro Tip 3/3Associated With Pain The term may evoke a sense of fear or discomfort as it often involves pain. Children may cry before getting an injection.