Malignant/məˈlɪɡnənt/ Definition 1 of 2Pro Tip 1/3Severity Level Malignant indicates a severe and worsening condition in a medical context. She was diagnosed with malignant hypertension. Pro Tip 2/3Progression Implication Use 'malignant' to imply the potential spread and dangerous growth of diseases. The patient's malignant cells were spreading rapidly. Pro Tip 3/3Context Sensitivity 'Malignant' in healthcare can evoke strong emotions; use it with sensitivity. The surgeon discussed the malignant nature of the disease respectfully.