Missus/ˈmɪsɪz/ Definition 1 of 3Pro Tip 1/3Affectionate Term Used fondly when referring to one's spouse, showing affection or humor. The missus made her famous lasagna tonight. Pro Tip 2/3Slightly Outdated Considered a bit old-fashioned, but still used in casual, modern conversation. Going out for a pint later, if the missus gives the nod. Pro Tip 3/3Not For Formal Use Avoid using 'missus' in formal settings or with people you're not familiar with. I'll check with my wife; 'missus' isn't appropriate here.