Missy/ˈmɪsi/ Definition 1 of 2Pro Tip 1/3Slightly Disrespectful May suggest impatience or annoyance when used by an elder or authority figure. Enough of that backtalk, missy! Pro Tip 2/3Familiar Tone Often used by someone who knows the young woman well, but it can be condescending. We don't do it that way, missy. Pro Tip 3/3Informal Situation Typically used in casual or informal settings, not in professional environments. You're in for a surprise, missy.