Mutant/ˈmjuːtənt/ Definition 1 of 2Pro Tip 1/3Science and Fiction Used often in science and sci-fi to describe beings with new traits. The science fiction novel featured a mutant with telekinetic abilities. Pro Tip 2/3Negative Connotations Sometimes implies abnormality or undesirability in casual contexts. The word 'mutant' is sometimes used derogatorily to refer to someone different. Pro Tip 3/3Biological Context Common in biology-related discussions about genetics and evolution. The biologist discussed how mutant species adapt over generations.