Nephew/ˈnefjuː/ Definition 1 of 1Pro Tip 1/3Family Terms Used to identify a specific male relative within an extended family. During family reunions, I enjoy catching up with my nephew. Pro Tip 2/3Gender Specific 'Nephew' always refers to a male relation; 'niece' is the female counterpart. My sister just had a baby boy; I'm now an uncle to a nephew! Pro Tip 3/3Affectionate Term Can express affection and familiarity; often used by aunts and uncles. My nephew and I have a special bond; we're like best friends.