Organ/ˈɔːrɡən/ Definition 1 of 3Pro Tip 1/3Anatomical Context Often used in discussions about health, biology, and anatomy. Doctors focus on how organs function together in the human body. Pro Tip 2/3Metaphorical Usage Can describe essential parts of systems or organizations. The operations department is the organ that keeps the company running. Pro Tip 3/3Not Always Internal Some organs can be visible, such as skin, the largest human organ. She used lotion to keep her skin, the body's largest organ, healthy.