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Size ImplicationPlay
The word emphasizes the smallness or insignificance of something. SlideThe room was clean, without a particle of dust visible.
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Figurative UsePlay
Often used to suggest a tiny amount or lack of something non-physical. SlideI don't have a particle of doubt in my mind.
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Negative SentencePlay
Commonly found in negative contexts to stress absence. SlideThere wasn't a particle of hope left for the lost sailors.