Piss/pɪs/ Definition 1 of 5Pro Tip 1/3Informal Setting The word 'piss' is casual and may be considered rude in polite company or formal situations. I need to piss — excuse me. Pro Tip 2/3Slang Variations 'Piss' has slang variations like 'take a piss' which means the same thing. I'm going to take a quick piss. Pro Tip 3/3Gender Neutral The term is used by all genders and does not vary in form. She needs to piss before we leave.