Puffy/ˈpʌfi/ Definition 1 of 3Pro Tip 1/3Emotional Indicator Puffy often describes physical symptoms related to emotions like crying or stress. Her eyes were puffy from hours of weeping. Pro Tip 2/3Allergic Reactions Used to describe body parts that swell due to allergies or irritation. His face got puffy after being stung by a bee. Pro Tip 3/3Not Always Negative Puffy can describe appealing fullness or roundness, not just swelling or bloating. The puffy clouds in the blue sky looked like cotton candy.