Sedative/ˈsedətɪv/ Definition 1 of 2Pro Tip 1/3Medical Context ‘Sedative’ is often used in medical settings to describe specific medications. The patient was given a sedative before the procedure. Pro Tip 2/3Not Always Drugs While usually drugs, 'sedative' can refer to any calming substance or activity. Listening to classical music can be a natural sedative. Pro Tip 3/3Avoid Dependency Use 'sedative' with care to imply that dependency on it for sleep or calm is risky. She became reliant on the sedative to fall asleep.