Segregate/ˈseɡrɪɡeɪt/ Definition 1 of 3Pro Tip 1/3Physical Barrier Segregate often implies the use of physical barriers to keep groups apart. The cafeteria is segregated into two zones by a glass partition. Pro Tip 2/3Negative Connotation 'Segregate' can imply unfair treatment when used for separating people. Employees felt segregated by the new office policy that seemed discriminatory. Pro Tip 3/3Not Interchangeable Avoid substituting 'segregate' for 'separate'. It is more specific and often deliberate. The event did not segregate attendees by ticket type.