Syndrome/ˈsɪndrəʊm/ Definition 1 of 3Pro Tip 1/3Not Always Genetic Some syndromes are genetic, others result from environmental factors or behaviors. Smoker's syndrome isn't inherited but caused by smoking. Pro Tip 2/3Cluster of Symptoms Remember that a 'syndrome' refers to a combination of symptoms, not just one. Irritable bowel syndrome involves a range of digestive system symptoms. Pro Tip 3/3Specific Disorders 'Syndrome' often indicates a recognized medical diagnosis. He was diagnosed with the Tourette syndrome by his doctor.