Upstate/ˌʌpˈsteɪt/ Definition 1 of 3Pro Tip 1/3Regional Usage Commonly refers to non-urban areas, hinting at quieter, less crowded places. She’s happier living upstate away from the city noise. Pro Tip 2/3Not Just New York While often used for New York, 'upstate' can describe the northern region of any state. My uncle farms upstate in Illinois. Pro Tip 3/3Travel Direction Used to indicate travel direction towards the state's northern parts. We're heading upstate this weekend for a getaway.