Use it to show you're pleasantly surprised by new, interesting information. They're moving to Spain next month? Is that a fact? How exciting!
Pro Tip 2/3
Confirmation Plea
Seek confirmation or further proof of what's just been stated. A comet will be visible tonight? Is that a fact? I'll grab my telescope!
Pro Tip 3/3
Avoid Overuse
If used too often, it could make you sound insincere or not genuinely interested. You got a new puppy? Is that a fact? And you won an award? Is that a fact?