The term can imply the task is large or complex, needing significant effort or time. The renovation of the kitchen was a big job of work that took three months.
Pro Tip 2/3
Idiomatic Use
Often used in informal contexts to describe a task one may not be looking forward to. Cleaning the garage is going to be a difficult job of work.
Pro Tip 3/3
Focus on Tasks
Refers to tasks often outside regular duties, like a special assignment or one-off project. My boss gave me a job of work to organize the year-end event.