Use the phrase to express doing something for personal joy, not external rewards. She studies art as an end in itself, not for a career.
Pro Tip 2/3
Misinterpretation Alert
Be careful not to confuse 'an end in itself' with being selfish; it refers to personal fulfillment. Volunteering is an end in itself, enriching my life deeply.
Pro Tip 3/3
Subtle Motivations
The phrase can suggest deeper, perhaps philosophical motivations for actions. For him, exploring nature is an end in itself.