Understand that it's an idiomatic expression commonly used in casual conversation. That car is a bargain, any way you slice it.
Pro Tip 2/3
Neutral Tone
The phrase doesn't imply good or bad outcomes; it's neutral and factual. It'll be busy at the mall today, any way you slice it.
Pro Tip 3/3
Emphasis on Certainty
Use it to emphasize a conclusion reached from any perspective or interpretation. Any way you slice it, they are the most qualified candidates for the job.