Often used ironically or humorously to emphasize how situations are typically difficult or undesirable. He's stubborn at the best of times, but during the negotiations, he wouldn't budge an inch!
Pro Tip 2/3
Challenging Norms
Implies that the norm is already challenging and any additional factors make it even more so. She finds public speaking nerve-wracking at the best of times; today she was downright petrified.
Pro Tip 3/3
Adding Emphasis
Used to add emphasis, often preparing for an admission that circumstances have become even worse. Traffic is bad at the best of times, but with the roadworks, it’s a complete nightmare.