The phrase emphasizes strong efforts to stay away from someone or something, suggesting a high level of dislike or fear. Since he had a terrible experience, he avoids that restaurant like the plague.
Pro Tip 2/3
Informal Tone
This phrase is informal and best used in casual speech or writing, not in formal contexts. I haven't been to the gym in months; I avoid it like the plague.
Pro Tip 3/3
Negative Connotation
It carries a negative connotation and shouldn't be used when a positive or neutral expression is required. She avoids discussing politics like the plague because it always leads to arguments.