Flesh and blood Definition 1 of 3Pro Tip 1/3Emotional Connection Expresses a close, personal relationship typically involving family ties. No matter what, she's my flesh and blood, and I love her. Pro Tip 2/3Not Literal It's a figurative way saying someone is a relative; not describing their physical presence. I was shocked to discover he's my flesh and blood. Pro Tip 3/3Colloquial Use Common in everyday speech to emphasize family relations or heritage. Even if we disagree, we're still flesh and blood.