Fuck off
Definition 1 of 3
Pro Tip 1/3Very Informal
Used mainly among friends or peers; can be offensive in formal settings. 
When he kept bothering me, I told him to fuck off.
Pro Tip 2/3Strong Emotion
Expresses anger or annoyance; softer alternatives are 'go away' or 'leave me alone'. 
She was so frustrated that she yelled 'fuck off!' at the top of her lungs.
Pro Tip 3/3Not At Work
Avoid using at work or professional environments; it's too casual and vulgar. 
I wanted to say 'fuck off' during the meeting, but I held my tongue.