Give up on Definition 1 of 3Pro Tip 1/3Emotional Impact Using 'give up on' can imply disappointment or loss of hope in a situation or person. After years of fighting, he gave up on the broken system. Pro Tip 2/3Persistence Context 'Give up on' is often used when someone has tried hard but decides to stop. Despite her efforts, she gave up on the unresponsive company. Pro Tip 3/3Not Instant This phrase suggests a gradual process, not an immediate one. After months of silence, I finally gave up on a response.