This expression suggests a lack of interest or emotion, not just physical tiredness. During the movie, I saw his expression change and his eyes glass over.
Pro Tip 2/3
Not Literal
'Glass over' is a metaphor; no actual glass is involved. As the conversation drifted to economics, her eyes glassed over.
Pro Tip 3/3
Momentary Change
The phrase often implies a temporary condition. He quickly snapped back to attention after his eyes glassed over.