Using 'hold against' indicates emotional burden or lingering negative feelings about someone's actions. Even years later, she held it against him for missing the wedding.
Pro Tip 2/3
Forbearance Appeal
Often used to ask for understanding or to excuse a foreseeable mistake or absence. Please don't hold it against me; I was really sick yesterday.
Pro Tip 3/3
Subjective Nature
The phrase is subjective; what one person holds against someone may vary greatly from another's perspective. I know you're upset, but I don't hold it against her.