'In a lather' emphasizes a very high level of emotion, more than just being worried or nervous. Minutes before his speech, he was in a lather, pacing back and forth.
Pro Tip 2/3
Negative Connotation
The phrase often implies a negative situation where calmness would be preferable. The entire team was in a lather over the lost files.
Pro Tip 3/3
Informal Usage
This idiom is informal, so use it mostly in casual conversation or creative writing. When he heard the sirens, he got into a lather, fearing the worst.