Use it when something is an expected result within a given situation or set of conditions. In the nature of things, people tend to trust those who are consistently reliable.
Pro Tip 2/3
Observable Patterns
Apply the phrase to describe regular, observable patterns in life or events that happen repeatedly. It's in the nature of things for technology to become outdated quickly.
Pro Tip 3/3
No Assigning Blame
Implies that the situation is neutral and not anyone's fault, as it is part of the normal course of events. In the nature of things, the market fluctuates without it being anyone's particular fault.