Indicates a very serious problem, usually causing worry or trouble. After the scandal, the politician was really in the shit.
Pro Tip 2/3
Informal
Used among friends or people of similar age. Not appropriate in formal situations. I didn't do my share of the group project and left my classmates in the shit.
Pro Tip 3/3
Vulgarity
Considered rude or offensive by some people, avoid using it around unfamiliar company. Mike got caught cheating; he's really in the shit now.