Refers to a field of study in college or university you choose to focus on. After much thought, I plan to major in psychology.
Pro Tip 2/3
Degree Specification
Often used to mention the specific degree or qualification one is aiming for through their studies. I'm going to major in electrical engineering for my Bachelor's degree.
Pro Tip 3/3
Commitment Indication
Implies a level of commitment to a particular subject that requires extensive study and understanding. She has chosen to major in marine biology, which means lots of lab time and research.