This phrase is used in informal situations among friends, family, or colleagues. Spill coffee on her carpet, and you'll never hear the end of it.
Pro Tip 2/3
Negative Connotation
The phrase often carries a negative tone, implying annoyance or frustration about the reminders. I forgot our anniversary once, and I've never heard the end of it.
Pro Tip 3/3
Emotional Impact
Using this phrase can express feelings of being overwhelmed by another's reaction. He caught that big fish, and we're never going to hear the end of it.