Cayenne/kaɪˈen/ Definition 1 of 3Pro Tip 1/3Heat Level Cayenne is very spicy; use it cautiously if you're not accustomed to heat. I only added a pinch of cayenne, it's too hot for me otherwise. Pro Tip 2/3Seasoning Variety Cayenne is a versatile spice, often found in different cuisines from Indian to Mexican. Cayenne is a staple in my spice rack for its versatility. Pro Tip 3/3Metaphorical Use Cayenne can symbolize something that adds piquancy or zest to a situation. Her witty remarks were the cayenne of the evening's conversation.