Cyst/sɪst/ Definition 1 of 2Pro Tip 1/3Medical Condition Cyst usually refers to a health issue, and demands a serious tone when discussed. She consulted her physician about the cyst. Pro Tip 2/3Non-cancerous Cysts are typically benign but may need medical attention if causing discomfort. Fortunately, the ultrasound confirmed the cyst was benign. Pro Tip 3/3Physical Discomfort Cysts can cause pain or other symptoms depending on their location and size. The cyst on her wrist made it difficult to write.