Depopulate/ˌdiːˈpɑːpjuleɪt/ Definition 1 of 3Pro Tip 1/3Historical Context Often used for historical events where populations decreased drastically. The bubonic plague depopulated entire medieval towns. Pro Tip 2/3Negative Connotation Implies a reduction in population that is undesirable or harmful. Natural disasters can quickly depopulate an affected area. Pro Tip 3/3Not Gradual Change Suggests a rapid or significant loss of population, not a slow decline. The war threatened to depopulate the country’s once bustling cities.