Despondent expresses a very strong feeling of hopelessness, more intense than just being sad or upset. He felt despondent when he realized his pet was missing.
Pro Tip 2/3
Temporary State
Use despondent to describe a temporary state of deep despair, not a person's general character. After hearing the bad news, she became despondent for days.
Pro Tip 3/3
Non-physical Appearance
Despondent is often used to describe someone's emotional appearance, observed through their behavior or expressions. His despondent gaze revealed his inner turmoil.