Encephalopathy/enˌsefəˈlɑːpəθi/ Definition 1 of 2Pro Tip 1/3Medical Condition Encephalopathy is always related to illness, referring specifically to brain health. Her encephalopathy was caused by a viral infection. Pro Tip 2/3Brain Function The term stresses on the malfunctioning aspect of the brain, not physical injuries. Memory loss could be a sign of encephalopathy. Pro Tip 3/3Diagnosis Encephalopathy is not self-diagnosable and requires medical tests to identify. Following an MRI, they confirmed it was encephalopathy.