Epidermis/ˌepɪˈdɜːrmɪs/ Definition 1 of 2Pro Tip 1/3Human Biology In humans, 'epidermis' refers to skin and implies a biological or clinical context. Medical students learn early about the functions of the epidermis. Pro Tip 2/3Protection Role 'Epidermis' indicates the skin's role as a protective barrier against the environment. Sunscreen is applied to protect the epidermis from UV rays. Pro Tip 3/3Visible Layer The 'epidermis' is the part of our skin we see, with no blood vessels present. When you tan, it's your epidermis that changes color.