Glutes/ɡluːts/ Definition 1 of 1Pro Tip 1/3Body Building Glutes are often mentioned in bodybuilding and fitness contexts to discuss muscle development. I'm hitting the gym to work on my glutes. Pro Tip 2/3Casual Tone Using 'glutes' is casual and common in everyday conversation, especially when talking about exercises. My glutes are sore from yesterday's leg day. Pro Tip 3/3Health and Wellness Discussions on posture, injury prevention, and physical therapy may refer to glutes. Strengthening your glutes can help alleviate lower back pain.