Guff/ɡʌf/ Definition 1 of 2Pro Tip 1/3Informal Usage Use 'guff' in casual conversations, not in formal situations. Quit your guff and get to the point. Pro Tip 2/3Dismissive Tone Saying 'guff' can show you think someone's ideas are not worth considering. I've had enough of your guff for today. Pro Tip 3/3Sarcasm Potential 'Guff' can be used sarcastically to mock something said. Nice try, but no more guff, please!