Guffaw/ɡəˈfɔː/ Definition 1 of 2Pro Tip 1/3Informal Use Use 'guffaw' in casual settings; it's too informal for serious or professional contexts. At the party, his story made me guffaw unexpectedly. Pro Tip 2/3Strong Amusement 'Guffaw' suggests a stronger reaction than a simple laugh, indicating something very funny. The clown's act had the audience guffawing in delight. Pro Tip 3/3Audible Volume A guffaw is loud and noticeable, more than a giggle or a chuckle. His guffaw could be heard across the crowded room.