Incise/ɪnˈsaɪz/ Definition 1 of 3Pro Tip 1/3Surgical Precision Used for exact or controlled cutting, suggesting a high level of skill or care. Only a trained professional should incise the delicate tissue. Pro Tip 2/3Sharp Tools Needed Implies use of a sharp instrument, such as a scalpel or knife. The craftsperson will incise the leather with a sharp blade. Pro Tip 3/3Protective Gear Safety measures should be taken when performing or practicing incisions. Wear gloves when learning to incise in a lab setting.